Download e-book for kindle: 25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman

By Pierre Hainaut, Klas G. Wiman

ISBN-10: 1402065647

ISBN-13: 9781402065644

P53 has emerged as a key tumor suppressor and critical aim for novel melanoma remedy. This booklet, written by way of world-leading p53 researchers together with lots of those that have formed the sector over the last 25 years, offers distinct insights into the growth of the sector and the clients for higher melanoma prognosis and treatment sooner or later.

Show description

Read Online or Download 25 Years of P53 Research PDF

Similar immunology books

Read e-book online Analytical Techniques for Clinical Chemistry: Methods and PDF

This publication information the function performed by way of analytical chemistry in fostering scientific learn. Readers will notice how a vast variety of analytical options aid all stages of medical study, from early levels to the implementation of functional functions. in addition, the contributing authors' cautious step by step suggestions allows readers to higher comprehend standardized ideas and stay away from daily difficulties which could come up within the lab.

Nima Rezaei's Cancer Immunology: Cancer Immunotherapy for Organ-Specific PDF

Melanoma Immunology is meant as an up to date, clinically appropriate evaluation of melanoma immunology and immunotherapy. This quantity specializes in the immunopathology and immunotherapy of organ cancers intimately. It truly explains their immunology and describes novel immunotherapy for particular cancers, together with pediatric strong tumors, hematologic malignancies, gastrointestinal tumors, dermis cancers, bone and connective tissue tumors, vital fearful process tumors, lung cancers, genitourinary tract tumors and breast cancers.

Gerald B. Pier, Jeffrey B. Lyczak, Lee M. Wetzler's Immunology, Infection, and Immunity PDF

Covers either the root ideas of immunology, one of the most fun in sleek biology and medication, and their software to the genuine international of illnesses and future health. This new textual content combines transparent narratives of the way the immune procedure capabilities depending normally on aiding facts from experiments.

Download PDF by Charlotte Esser: Environmental Influences on the Immune System

This ebook brings jointly articles at the overarching subject matter of ways the surroundings shapes the immune approach. The immune approach is usually assumed to reply to destructive pathogens equivalent to micro organism and viruses. although, innocuous micro organism, chemical substances, tension, common foodstuff and different components may also set off, form or intervene with the immune approach, frequently generating adversarial results.

Additional info for 25 Years of P53 Research

Example text

3055-3062. , Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science, 1990. 249: 1049-1051. , Sun Y. Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells. Cancer Biol. , 2003. 2: 406-415. , Rechavi G. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the co-activator Zac-1. Oncogene, 2002. 21: 1469-1476. J. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associtaed with the same 54kd cellular protein in transformed cells.

Prives C. The C-terminus of p53: the more you learn the less you know. Nat Struct Biol 2001; 8:730-2. , Roeder R. G. Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53. Cell 2004; 117:735-48. Anderson M. , Tegtmeyer P. Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol 1997; 17:6255-64. , Anderson C. W. Post-translational modifications and activation of p53 by genotoxic stresses.

1996). Therefore it is possible that one way to increase p53 function in cells would be through protein-protein interactions with this intrinsically destabilizing domain. , 1996b). , 2000). , 1996). , 1994). , 1998). Furthermore, in the same study a peptide spanning this domain was shown to increase p53 DNA binding when titrated in trans in a manner that required the presence of residues 80-93 and 363-393 (another autoinhibitory region that will be discussed below). The N-terminus of p53 is highly post-translationally modified (reviewed in Appella & Anderson, 2001).

Download PDF sample

25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman

by Donald

Rated 4.67 of 5 – based on 20 votes