By Pierre Hainaut, Klas G. Wiman
P53 has emerged as a key tumor suppressor and critical aim for novel melanoma remedy. This booklet, written by way of world-leading p53 researchers together with lots of those that have formed the sector over the last 25 years, offers distinct insights into the growth of the sector and the clients for higher melanoma prognosis and treatment sooner or later.
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Additional info for 25 Years of P53 Research
3055-3062. , Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science, 1990. 249: 1049-1051. , Sun Y. Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells. Cancer Biol. , 2003. 2: 406-415. , Rechavi G. A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the co-activator Zac-1. Oncogene, 2002. 21: 1469-1476. J. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associtaed with the same 54kd cellular protein in transformed cells.
Prives C. The C-terminus of p53: the more you learn the less you know. Nat Struct Biol 2001; 8:730-2. , Roeder R. G. Ordered Cooperative Functions of PRMT1, p300, and CARM1 in Transcriptional Activation by p53. Cell 2004; 117:735-48. Anderson M. , Tegtmeyer P. Reciprocal interference between the sequence-specific core and nonspecific C-terminal DNA binding domains of p53: implications for regulation. Mol Cell Biol 1997; 17:6255-64. , Anderson C. W. Post-translational modifications and activation of p53 by genotoxic stresses.
1996). Therefore it is possible that one way to increase p53 function in cells would be through protein-protein interactions with this intrinsically destabilizing domain. , 1996b). , 2000). , 1996). , 1994). , 1998). Furthermore, in the same study a peptide spanning this domain was shown to increase p53 DNA binding when titrated in trans in a manner that required the presence of residues 80-93 and 363-393 (another autoinhibitory region that will be discussed below). The N-terminus of p53 is highly post-translationally modified (reviewed in Appella & Anderson, 2001).
25 Years of P53 Research by Pierre Hainaut, Klas G. Wiman